Iodin preparation.



UNITED STA -Es PATENT OFFICE.

EMIL' FISCHER, OF BERLIN, GERMANY, ASSIGNOR TO FARBENFABRIKEN OF ELBERFELD 00., OF NEW YORK, N. Y., A CORPORATION OF NEW, YORK.

IODIN PREP AHA'Tl ON.

Specification of Letters Patent.

Patented.'.Dee. 25, 1906.

' To all whom it may concern:

provement in Iodin Preparations; and There:

y declare the following to be a clear and exact description of my invention.

In order to produce the therapeutic effect of iodin in the human system, potassium iodid has been mostly used. This substance, however, is known to produce frequently symptoms for which the medical term iodism is a plied. These symptoms are sore throat an eyes, nausea, eczema, and the like. Again, potassium iodid has a peculiar taste' against which many patients rebel. The hitherto-known therapeutic substitutes for potassium iodid are mostly oils'possessing a disagreeable taste.

My new reparations which I have obtained by tl ie action of hydrogen iodid on high molecular acids of the oleic, seriessuch as oleic acid, 'erucic acid, brassidic acid elaidic acid, or the like-and by the transformation of the free acids into their salts distinguish themselves by being solid substances which have no taste. Clinical experience has shown that the symptoms of iodism are very rarely observed in their administration and that iodin in my preparations acts much more effectively than in the form of potasbodies the sium iodid.

For the production of my new iodin-substituted acids obtained by the ac- -tion of hydrogen iodid dissolved in glacial acetic acid on the high molecular aclds of the oleic series are transformed into the salts of the alkaline earths. -The preparation of these salts of the iodin derivatives of the high molecular fatty acids must be carried out in such a manner that the resulting salts are neutral, because salts containing free acids have a faint odor and taste and cannot be'kept without decomposition. Under the term high molecular acids of the oleic series and high molecular fatty acids those acids are generally understood which contain more Example 1: Twenty parts of erucic acid.- and a solution of hydrogen iodid in glacial acetic acid, which is saturated at a low temperature and contains from ten to eleven parts of hydrogen iodid, are heated for about three to five days to from to centigrade in a closed vessel under constant stirring. The erucic acid remains undissolved for the most part, but nevertheless combines with hydrogen iodid. After cooling, the product of reaction is mixed with much .water, and free iodin contained in it is removed by reduction. with sulfurous acid. By cooling the liquid with ice the monoi'odobehenic acid, which when first/formed is an oil, solidifies. It i'sfiltered off, dissolved in ether, and the ethereal solution is shaken with a highly-diluted sulfurous acid to remove free oidin. After evaporation of the ether the monoiodobehenic acid remains in the'shape of a whitish solid substance. It melts at bloo'd heat and has the formula C H IO Twenty-five parts of crystallized chlorid of calcium containing waterof crystallization are dissolved in one hundred and twenty parts of hot alcohol and an excess of gaseous ammonia is passed through the liq uid. When the preci itation of ammonium' chlorid has been comp eted, one hundred and thirty parts of alcohol (ninety-two per cent.) are added. It is then cooled to ordinary temperature. To the cold mixture 9. solution of forty-fourparts of the above monoiodobehenic acid in one hundred and twenty parts of alcohol is slowly added under stirring. The calcium salt of monoiodobehenic acid separates out in the she. e of a colorless voluminous precipitate. t is filtered off with suction, pressed, washed with alcohol, mixed up by stirring with cold water, filtered off with suction, and subsequently washed with water until the. wash-water is free from chlorin. dried in-vacuo. The calcium salt thus "ob" tained-is a colorless and tasteless powder, 'almost insoluble in water and alcohol. be kept in the dark for a long tiIne without suffering decomposition. In the light it slowly assumes a slightly-yellow color. It is formed according to the following equation:

behenicl'acid with calcium salts' 'in 'squeous It is then'washed with alcohol and too It can by the acid by shaking it at ordinary tem- (about still contains small amounts of the free acid,

aqueous caustic-potash solution.

of met-hylic alcohol is then slowly run into henic acid is dissolved in'a somewhat larger i quantity of caustic potash than is required perature with highly-diluted caustic potash,

one-fiftieth normal.) The calculated quantity of a dilute aqueous solution of chlorid of calcium is added to the solution and it is stirred until the colorless flocculent precipitate has settled. It is filtered off with suction, washed with water, then with alcohol to remove small quantities of free iodobehenic acid which may be present, and dried in vacuo. This purification is not necessary if an aqueous solution of chlorid of calcium mixed with an excess of ammonia be used. The precipitated calcium salt of iodobehenic acid is neutral and forms after being washed with water and dried in vacuo a white tasteless and odorless powder.

Example .3: The same salt may also be prepared as follows: One part oi. iodobehenic acid is shaken at ordinary temperature and for three to five days with one hundred parts of a saturated aqueous solution of calcium hydroxid. It is filtered off and washed with water. The resulting calcium salt, which is then heated with alcohol to melt it and carefully mixed up with the liquid by stirring. After cooling, the salt forms a color less powder which is filtered on and dried in ca-cuo.

Example 4: In order to prepare the strontium salts of monoiodo'behenic acid, I may proceed as follows: Forty-four parts of crystallized strontium chlorid containing water of crystallization are dissolved in sixty parts of hot water, twelve hundred parts of methylic alcohol are added thereto, and an excess of gaseous ammonia is passed through the liquid. A solution of one hundred parts of iodobehenic acid in eight hundred parts the above solution containing the strontium compound while constantly stirring. The precipitated strontium salt is filtered. off, washed with methylic alcohol, then with water, and finally again with methylic alcohol, and dried in vacuo. It is a granular, colorless, tasteless, and odorless powder.

Example 5: The same salt results if I proceed as follows: hionoiodobehenic acid is dissolved by shaking it with a little more than the calculated quantity of one-fiftieth normal A- dilute aqueous solution of chlorid of strontium of a strength which is equivalent to the potash is added while vigorously stirring. The precipitate is then further treated as described under Example 2.

-Example 6-: The strontium salt may also be obtained as follows: A solution of four ipta'rts of crystallized strontium hydroxid in i ve hundred parts of water is allowed to l line earths of the monoiodin-substituted deflow on ten parts of iodobehenic acid. It'is heated to-about 35 centigrade until the acid melts, and the mixture is then vigorously stirred for about seventy to one hundred hours. It is advantageous to heat from time to time to 35 centigrade to melt the acid which has not taken part in the reaction. To separate the resulting strontium salt from admixed small amounts of unchanged acid, it is filtered off and heated with alcohol until it melts. The salt solidifies while cooling to a solid compound containing 24.2 per cent. of iod in. A solution of iodobehenic acid in ether or ligroin may also be used for the preparation of the strontium salt. The monoiodostearic acid is obtained from oleic acid in the same manner as the-iodobehenic acid from erucie acid. aration of the monoiodostcaric acid to employ a somewhat larger quantity of hydrogen iodid on account of the smaller mo ecular weight of oleic acid. The iodostearic acid thus obtained is at ordinary temperature a faint yellow oil.

Example 8: The process for preparing the calcium salt of iodostearic acid is the same as is described under Example 1 for the preparation of the calcium salt of iodobehenic acid. After having washed with water the calcium salt it is advisable to extract it with acetone instead of with alcohol. By this treatment it loses its viscosityand is converted into a colorless and tastelesspowder.

Example 9: The calcium salt of iodostearic acid may also be obtained as follows: A solution of iodostearic acid in a little more than the calculated quantity of dilute caustic pot-. ash is mixed while shaking with a dilute solu tion of chlorid of calcium, the strength of which is equivalent to the alkali. The precipitate obtained is filtered on with suction, washed with water, and dried in Macao. Slight quantities of free iodostcaric acid be ing sometimes contained in the product are got rid of by washing it with acetone.

Example .10: The strontium salt of iodostearic acid is prepared in the way described underExample 9 for the calcium salt, employing a solution of chlorid of strontium instead of calcium chlorid. After the washing with water it is advisable to carefully-extract the salt with acetone. It is after being dried in vacuo a colorless, tasteless, and voluminous powder. The preparation of other nionoiodin substituted derivatives of high molecular fatty acids and their salts of It is advantageous for the prep- IIO alkaline earths and of magnesium is carried Corrections in Letters Patent N's. 83%,563.

rix atives of high molecular fatty acids ob-i monoiodobehenic acid (C' H IoQ Ca. 0bturned from the corresponding high inolecutained from monoiodobehenic acid which is a lar acids of the oleic series which are solid,

stable bodies, tasteless, colorless, and insoluble in Water, substantially as hereinbefore described.

2. The herein-described salts of the alkaline earths obtained from monoiodobehenic acid which aria solid stable bodies, tasteless, colorless and insoluble in water, substantially as A c nbefore described.

3. The herein-described calciun salt of record of the case in the Patent Oflice.

[seen] solid stable body, tasteless, colorless and insoluble in water.

In testimony whereof I have signed my name in the presence of two subscribing Witnesses.

EMIL FISOHEI Witnesses:

HENRY HASPER, WOLDEMAR It is hereby certified that in Letters Patent No. 839,569, granted December 25,1906,- 1' upon the application of Emil Fischer, of Berlin, Germany, for an'improveinent in Iodin Preparations, errors appear requiring correction, as follows: On page 1, line '74, 'thelword i oidin should read iodin; page 2, lines 80-81, the words The monoiopdostearic should commence a new paragraph, and same page, line 119, the words The preparation of should commence a new paragraph; and that the said Letters Patent should be read with these corrections therein that the same may conform to the Signed and sealed this 15th day of January, A. D. 1907.

F. I. -ALLEN,

Commissioner of Patents Corrections in Letters Patent N's. 83%,563.

rix atives of high molecular fatty acids ob-i monoiodobehenic acid (C' H IoQ Ca. 0bturned from the corresponding high inolecutained from monoiodobehenic acid which is a lar acids of the oleic series which are solid,

stable bodies, tasteless, colorless, and insoluble in Water, substantially as hereinbefore described.

2. The herein-described salts of the alkaline earths obtained from monoiodobehenic acid which aria solid stable bodies, tasteless, colorless and insoluble in water, substantially as A c nbefore described.

3. The herein-described calciun salt of record of the case in the Patent Oflice.

[seen] solid stable body, tasteless, colorless and insoluble in water.

In testimony whereof I have signed my name in the presence of two subscribing Witnesses.

EMIL FISOHEI Witnesses:

HENRY HASPER, WOLDEMAR It is hereby certified that in Letters Patent No. 839,569, granted December 25,1906,- 1' upon the application of Emil Fischer, of Berlin, Germany, for an'improveinent in Iodin Preparations, errors appear requiring correction, as follows: On page 1, line '74, 'thelword i oidin should read iodin; page 2, lines 80-81, the words The monoiopdostearic should commence a new paragraph, and same page, line 119, the words The preparation of should commence a new paragraph; and that the said Letters Patent should be read with these corrections therein that the same may conform to the Signed and sealed this 15th day of January, A. D. 1907.

F. I. -ALLEN,

Commissioner of Patents Corrections in Letters Patent No. 839,569.

, Iodin Preparations, errors appear requiring correction, as follows:

upon the application of Emil Fischer, of Berlin, Germany,

It is hereby certified that in Letters Patent No. 839,569, granted December 25, 1906,

for an improvement in On page 1., line 74, the word oiclin should read iodin; page 2, lines 80-81, the words The monoiodostearic" should commence a new paragraph, and same page, line 119, the words The preparation of should commence a new paragraph; and that the said Letters Patent should be read with these corrections therein that the same may conform to the record of the case in the Patent Ofiice.

Signui and sealed this 15th day of January, A. 1).. 1907.

[sic/in] F. I. ALLEN,

Commissioner of Patents. 

